منابع مشابه
A New Chromatin-Cytoskeleton Link in Cancer.
The set domain containing 2 (SETD2) histone methyltransferase, located at 3p2, specifically trimethylates lysine 36 of histone H3 (H3K36me3). H3K36me3 is an active mark involved in transcriptional elongation and RNA processing and a key regulator of DNA repair. In fact, SETD2 is the only methyltransferase that "writes" the H3K36me3 mark. Recent results from Park and colleagues have found a new ...
متن کاملEpigenetics: a new link between nutrition and cancer.
Emerging studies suggest that dietary components can affect gene expression through epigenetic mechanisms. Epigenetic modifications are heritable and potentially reversible changes in gene expression that do not require changes in the DNA sequence. The main mechanisms of epigenetic control in mammals are DNA methylation, histone modifications, and RNA silencing. The potential reversibility of e...
متن کاملThe Diabetes-Cancer Link
Type 2 diabetes is associated with increased risks for several cancers, including colon,1 postmenopausal breast,2 pancreatic,3 liver,4 endometrial,5 and bladder6 cancers and non-Hodgkins lymphoma.7 Type 2 diabetes is also linked to a modest decrease in the risk for prostate cancer.8 However, diabetes does not reduce aggressive forms, and prostate cancer mortality rates are higher among men with...
متن کاملAbiotic transformation of chlorpyrifos to chlorpyrifos oxon in chlorinated water.
In vivo transformation of chlorpyrifos to chlorpyrifos oxon is believed to be a prerequisite for this insecticide to display acute toxicity to organisms. We discovered that active chlorine dispersed in water causes the rapid abiotic transformation of chlorpyrifos to chlorpyrifos oxon. The proposed mechanism for the transformation is an electrophilic attack by hypochlorous acid (HOCl) on the thi...
متن کامل“vitality” a missing link in adjustment to childhood cancer
background: a number of randomized trial studies and longitudinal researches emphasize that despite problems in social adjustment and cognitive damages, children with cancer demonstrate good emotional adjustment. methods: most of the research findings in this area are obtained using objective tools such as questionnaires. “vitality of children”, as a drawing tool, was used as a basis to draw a ...
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ژورنال
عنوان ژورنال: Environmental Health Perspectives
سال: 2005
ISSN: 0091-6765,1552-9924
DOI: 10.1289/ehp.113-a158b